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The Arabidopsis O

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Abstract Plant development requires coordination among complex signaling networks to enhance the plant's adaptation to changing environments. DELLAs, transcription regulators originally identified as repressors of phytohormone gibberellin signaling, play a central role in integrating multiple signaling activities via direct protein interactions with key transcription factors. Here, we found that DELLA is mono-O-fucosylated by the novel O-fucosyltransferase SPINDLY (SPY) in Arabidopsis thaliana. O-fucosylation activates DELLA by promoting its interaction with key regulators in brassinosteroid- and light-signaling pathways, including BRASSINAZOLE-RESISTANT1 (BZR1), PHYTOCHROME-INTERACTING-FACTOR3 (PIF3) and PIF4. Moreover, spy mutants displayed elevated responses to gibberellin and brassinosteroid, and increased expression of common target genes of DELLAs, BZR1 and PIFs. Our study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development. This finding may have broader importance because SPY orthologs are conserved in prokaryotes and eukaryotes, thus suggesting that intracellular O-fucosylation may regulate a wide range of biological processes in diverse organisms. TypeJournal article SubjectArabidopsisArabidopsis ProteinsFucosyltransferasesRepressor Proteins Permalinkhttps://hdl.handle.net/10161/15816 Published Version (Please cite this version)10.1038/nchembio.2320 Publication InfoZentella, Rodolfo; Sui, Ning; Barnhill, Benjamin; Hsieh, Wen-Ping; Hu, Jianhong; Shabanowitz, Jeffrey; ... Sun, Tai-Ping (2017). The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA. Nat Chem Biol, 13(5). pp. 479-485. 10.1038/nchembio.2320. Retrieved from https://hdl.handle.net/10161/15816.This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal. Collections Scholarly Articles More InfoShow full item record Scholars@Duke Boyce

Michael Scott Boyce Associate Professor of Biochemistry The Boyce Lab studies mammalian cell signaling through protein glycosylation. For the latest news, project information and publications from our group, please visit our web site at http://www.boycelab.org or follow us on Twitter at https://twitter.com/BoyceLab. Sun

Tai-ping Sun Professor of Biology The diterpenoid phytohormone gibberellin (GA) plays pivotal roles in regulating growth and development throughout the life cycle of higher plants. Mutations affecting GA biosynthesis or GA response were the key to control plant stature in wheat and rice that led to dramatically increased grain yield and contributed greatly to the success of the ‘Green Revolution’ in the 1960s. By multi-faceted approaches using the reference plant Arabidopsis, my lab has made major brea Zhou

Pei Zhou Professor of Biochemistry Protein-protein interactions play a pivotal role in the regulation of various cellular processes. The formation of higher order protein complexes is frequently accompanied by extensive structural remodeling of the individual components, varying from domain re-orientation to induced folding of unstructured elements. Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for macromolecular structure determination in solution. It has the unique advantage of being capable of elucidati Alphabetical list of authors with Scholars@Duke profiles.

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The Arabidopsis O

The Arabidopsis O

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